What stops a new chromosome variant appearing as a unique mutation from increasing in frequency?

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Question:What stops a new chromosome variant appearing as a unique mutation from increasing in frequency?

1.It is because polyploidy is a rare process

2.it will interbreed with majority form causing heterozygotes to be inferior

3.allopatric speciation does not necessitate reinforcement

4.all of these

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  1. What stops a new chromosome variant appearing as a unique mutation from increasing in frequency?
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