X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

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Question: X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

1.activation of B cells by T-independent antigens

2. failure of B cells to provide co-stimulation for Th2 activation

3.failure of Th2 cells to provide co-stimulation for B cell isotype switching

4.failure of Th2 cells to provide co-stimulation for B cell proliferation

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  1. X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be
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